Protective and therapeutic efficacy of Mycobacterium smegmatis expressing HBHA-hIL12 fusion protein against Mycobacterium tuberculosis in mice.

Tuberculosis (TB) remains a major worldwide health problem.The only vaccine against TB, Mycobacterium bovis Bacille Calmette-Guerin (BCG), has demonstrated relatively low efficacy and does not provide satisfactory protection against the disease.More efficient vaccines and improved therapies are urgently needed to decrease the worldwide spread and b

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